Clinical

At the outset of the COVID-19 pandemic, the presumed telltale signs of infection were obvious: fever, respiratory distress, chills. Then more subtle symptoms like diminished senses of loss and smell became more apparent. Eventually, we understood that some people developed few (or even no) symptoms—but that they could still infect others and be “sick” for months themselves. Unfortunately, the learning curve continues as an article just published by JAMA Network reveals that the proportion of …

You know that complete vaccination, including a full two-dose regimen plus a booster shot, offers excellent protection against COVID-19 infection. You’re also aware that recovering from the virus leaves patients with protection from natural antibodies. Now there’s research suggesting that vaccinated patients who experience and recover from breakthrough cases may have the best protection man and nature can provide. The authors of a Research Letter published by the Journal of the American Medical Association wrote …

Just 3 weeks after the first Omicron-related diagnosis of COVID-19 in the United States, the Centers for Disease Control and Prevention reports that this latest variant of the virus has become the dominant one in this country, accounting for 73% of new cases here as of this writing. Bear in mind that’s the national figure; Omicron is even more dominant in New York, New Jersey, and parts of the Midwest, South, and Pacific Northwest. The …

With increasing spread of the Omicron COVID-19 variant, some states have already upgraded their pandemic status (New Jersey, for example, just went from yellow [moderate] to orange [high]). That doesn’t bode well for the future, given predictions from the PolicyLab at Children’s Hospital of Philadelphia that the entire country will see a dramatic jump in new cases over the next 4 weeks. A ripple effect that began with travel and gatherings over Thanksgiving weekend is …

Multiple tools to detect pulmonary embolism are at the urgent care provider’s disposal. And yet, misses happen. The Journal of the American Medical Association just published an article on research that tested an alternate method to detect PE, combining the YEARS rule with age-adjusted D-dimer threshold—and the authors concluded that this method “did not lead to an inferior rate of thromboembolic events compared with a conventional diagnostic strategy.” The cluster-randomized crossover noninferiority study focused on …

As JUCM News has reported, rates of influenza are increasing across the United States and across age groups at a very precarious time, with rates of COVID-19 also on the rise. The passage of another week brings more of the same, as the Centers for Disease Control and Prevention, as well as regional and national media, are reporting that the climb continues but also sharing insights as to what’s fueling it. One of key culprits …

New data out of the United Kingdom confirm what has been presumed (and been concerning): The two-dose regimen of vaccination against COVID-19 is insufficient to protect against the Omicron variant. This isn’t surprising, given the fact that so many people are vaccinated but cases are climbing around the world, including in the United States. However, the University of Oxford researchers did not find evidence that infection with Omicron led to increased risk for severe disease, …

The success of vaccinations against much older viruses has been part of the rallying cry for people trying to convince others that it is not only wise, but the responsible thing to do to get vaccinated against COVID-19. Unfortunately, we collectively seem to have forgotten that we can’t afford to let vigilance lapse once we think we’ve tamed a virus. We could be at a precarious point with measles right now, for example. The past …

A year ago at this time, fear was high that the United States would be hit with a “twindemic” of influenza and COVID-19. It never materialized, largely due to the fact that measures taken to protect ourselves from the SARS-CoV-2 virus (social distancing, frequent handwashing, wearing a face cover, etc.) had the unintended benefit of keeping flu activity low. This year, however, with many people vaccinated against COVID-19 and letting other measures slide, we might …

Too many patients are telling the media that they refuse to get vaccinated against COVID-19 because “it doesn’t work,” pointing to the growing number of breakthrough cases as justification. While it’s true that the number of confirmed cases in patients who are fully vaccinated continues to increase (and is likely to grow more steeply now that the Omicron variant is spreading around the globe), the associated death rate is simply not keeping pace. In fact, …