Even patients who accept that vaccination and boosters are effective in reducing risk for COVID-19 infection may be getting complacent, whether they’ve dodged infection so far or not. However, data published by the New England Journal of Medicine based on the cases of 1.25 million people 60 years of age and older in Israel confirm that a fourth dose of vaccine really does confer more protection against the virus than three doses. The results amplify an earlier Israeli study reflecting the care of 364,000 individuals in the same age category. In the latest study, patients who got a fourth dose of the Pfizer-BioNTech vaccine were at least three times less likely to develop severe COVID-19 compared with those who received only three doses.

Think Three Shots Are Enough Protection Against COVID-19? Think Again