Practice Management
Kids who have irritable bowel syndrome with constipation (IBS-C) now have a new treatment option as the Food and Drug Administration (FDA) this month approved linaclotide for pediatric patients 7 years and older. There is no known underlying cause for IBS-C in children, and symptoms include chronic constipation and abdominal pain. Linaclotide is the first treatment approved for IBS-C in pediatric patients with a recommended dose of 145 mcg orally once daily. A 12-week, double-blind, …
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A systematic review and meta-analysis of 155 studies evaluated the literature on the link between any viral infection and the odds of heart attack and stroke risk. Authors found influenza and COVID infections raised such risks as much as 3-to-5-fold in the weeks following the initial infection, as published in the Journal of the American Heart Association. Also noted in a related news release on the study, overall, the findings suggest acute and chronic viral …
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In a study of 9,258 adults with type 2 diabetes, frequent continuous glucose monitoring (CGM) use was linked to significantly greater HbA1C reductions over 12 months compared with no CGM use, as published in JAMA Network Open. Patients using their CGM devices on 270 days per year or more achieved a mean HbA1C decrease of −1.52 percentage points (95% confidence interval [CI], −1.73 to −1.32 percentage points) vs −0.63 percentage points in nonusers (95% CI, …
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From 2010 to 2024, prescriptions for glucagon-like peptide 1 receptor agonists (GLP-1RAs) increased substantially among individuals with type 2 diabetes (T2D) and obesity, according to a research letter in JAMA Network Open, which examined electronic medical records of more than 300 million Americans. Rates rose from 2.4% to 34.3% among individuals with both T2D and obesity; from 0.6% to 13.7% in those with T2D only; and 0.04% to 7.1% in those with obesity only. The …
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A meta-analysis published in the New England Journal of Medicine of 511 studies found peer-reviewed evidence supports the safety and effectiveness of vaccines for COVID-19, respiratory syncytial virus (RSV), and influenza during the 2025–2026 season. The COVID-19 vaccines for the XBB.1.5 variant had a pooled vaccine effectiveness against hospitalization of 46-50% among adults and 37% among adults with weakened immune systems, according to the analysis. For RSV, vaccines had pooled estimates of 68% for maternal …
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The Food and Drug Administration has approved the oral drug elinzanetant for the treatment of moderate to severe hot flashes due to menopause. It’s a novel nonhormonal drug with dual neurokinin-targeted therapy (NK1 and NK3 receptor antagonist), according to the manufacturer’s press release. Elinzanetant offers another option for patients, in addition to 2 other nonhormonal therapies: NK3 receptor antagonist fezolinetant; and the antidepressant paroxetine. Two phase III trials with a total of 796 menopausal women …
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In a cross-sectional study of 3,378 influenza-positive children across 7 U.S. pediatric hospitals, researchers found a substantial decline in antiviral prescribing in the emergency department during the COVID-19 pandemic, as published in JAMA Network Open. Among 2,514 children at higher risk of severe influenza, 32.2% received antivirals in the prepandemic era (December 1, 2016, to March 31, 2020), compared with 15.6% during late pandemic era (July 1, 2021, to June 30, 2023)—a 53% relative decrease. …
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The California Department of Public Health has issued a warning that clade I mpox may be spreading in the state, “primarily impacting communities of gay and bisexual men,” after 3 cases of this rare, more severe strain of mpox were confirmed. At least 1 case occurred in a person with no recent travel who was recently hospitalized and has been discharged to recover at home, indicating that person-to-person community spread of clade I mpox is …
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In 2023, the American Heart Association (AHA) introduced a staging construct for cardiovascular, kidney, and metabolic (CKM) syndrome. Subsequently, a 2024 JAMA article found among a study population of 10,762 U.S. adults, almost 90% met criteria for CKM syndrome (stage 1 or higher), and 15% met criteria for advanced stages between 2011 and 2020. In a new survey of 4,000 adults, AHA found that only 12% of respondents had heard of CKM, and 68% incorrectly …
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In a randomized clinical trial of 800 adults aged 65 years or older with chronic low back pain, both standard acupuncture and enhanced acupuncture with maintenance sessions significantly improved disability related to back pain compared with usual medical care, as published in JAMA Network Open. At 6 months, the adjusted mean disability score (Roland-Morris Disability Questionnaire) improved by −1.0 for standard acupuncture and −1.5 for enhanced acupuncture vs usual care with benefits sustained at 12 …
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