Journal of Urgent Care Medicine

Two New Antibiotics Expand Treatment Options For Gonorrhea

The Food and Drug Administration has approved 2 new oral antibiotics for the treatment of uncomplicated gonorrhea, expanding therapeutic options amid growing drug resistance. Zoliflodacin was approved based on results from a multinational phase 3 trial involving 930 patients. In the study, a single oral dose of zoliflodacin was noninferior to a regimen of injectable ceftriaxone plus oral azithromycin. The study showed 91% of patients who took zoliflodacin were cured, and 96% of patients who …

Outpatient Baloxavir Demonstrates Fewer Influenza Hospitalizations Than Oseltamivir

According to a U.S. retrospective analysis published in the International Journal of Infectious Diseases, real-world outcomes suggests that baloxavir may offer more reduction in downstream healthcare utilization among influenza outpatients compared to oseltamivir. The study evaluated electronic health records from 69 healthcare organizations, identifying more than 75,000 treated patients aged 5 years and older who received either oseltamivir (73,899) or baloxavir (1,592) from 2016 to 2023. Across 1-, 3-, and 6-month follow-up periods, baloxavir users …

Benefits Of Weight Loss Meds Don’t Last After Discontinuation

In a post-hoc analysis of a trial that measured weight gain and cardiometabolic factors among participants who used tirzepatide for 36 weeks, researchers found that among participants with obesity who stopped tirzepatide, a large majority had regained much of their weight—and that majority also lost more of the cardiometabolic benefits compared to those who maintained their weight reduction. In other words, those who did not keep the weight off after stopping tirzepatide also lost the …

Peanut Patch Slowly Builds Kids’ Tolerance

Just as more evidence is emerging that supports exposure to peanuts for young children as a way to avoid future peanut allergies, a study presented at the Annual Scientific Meeting of the American College of Allergy, Asthma and Immunology (ACAAI) found that an epicutaneous patch continued to build peanut tolerance over 3 years, according to a press release. The immunotherapy patch delivers small amounts of peanut protein through the skin, slowly building tolerance and reducing …

GLP-1 Users May Have Higher Risk For Chronic Cough

Use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) may be associated with chronic cough, as published in JAMA Otolaryngology–Head & Neck Surgery. A large study of more than 2 million people with type 2 diabetes across 70 healthcare organizations suggests that adults prescribed a GLP-1RA had a 12% higher risk for developing a new cough persisting for more than 8 weeks, compared with people prescribed other medications, including dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter 2 (SGLT2) …

Antibiotic Resistance For Gonorrhea Seen As Global Health Threat

New data from the World Health Organization (WHO) warns of a rise in drug-resistant gonorrhea worldwide. According to a news release from the agency’s Enhanced Gonococcal Antimicrobial Surveillance Program, resistance to ceftriaxone and cefixime—2 first-line antibiotics for gonorrhea—has increased. From 2022 to 2024, ceftriaxone resistance rose from 0.8% to 5%, while cefixime resistance rose from 1.7% to 11%. Resistance to azithromycin, which is often used alongside ceftriaxone or cefixime, also increased from 0.5% to 4%, …

Forthcoming Asthma Guidelines Look To Address Systemic Corticosteroid Use

Anticipated updates for asthma treatment guidelines are shifting away from oral or systemic corticosteroids because of increasing evidence of long-term harm. Negative effects can come from even short, intermittent use, according to coverage in MedPage Today of the American College of Allergy, Asthma and Immunology meeting. Studies show that as few as 3 or 4 steroid bursts over a lifetime may lead to side effects such as bone loss, metabolic disorders, and adrenal suppression. The …

Stormy Days Equal More ED Visits For Those With Asthma

A 5-year study that was presented this month at the annual scientific meeting of the American College of Allergy, Asthma and Immunology finds that thunderstorms can trigger measurable increases in asthma-related emergency department (ED) visits. Researchers analyzed 4,439 asthma-related visits across 3 hospitals in Kansas from January 2020 to December 2024, during which time, they identified 38 thunderstorm days. Data showed the mean number of admissions on storm days (17.91) was significantly higher than on …

Younger Adults With High Cholesterol Lag In Statin Treatment

A large study of 771,681 adults aged 18–39 found that young people with high LDL cholesterol rarely begin statin therapy, despite guideline recommendations, as published in the Journal of the American College of Cardiology and presented at the American Heart Association’s 2025 Scientific Sessions. Among young adult members of Kaiser Permanente Southern California with LDL-C of 190 mg/dL or higher, just 28.4% started a statin drug within 1 year, and less than half (45.7%) had …

Watchful Waiting Works Well For Acute Otitis Media

A large multi-system analysis of 140,579 pediatric acute otitis media (AOM) visits published in the Journal of the Pediatric Infectious Diseases Society found “watchful waiting” was used in only 15.6% of cases—even though watchful waiting is often a beneficial approach, according to the authors. The watchful waiting group was either sent home without a prescription (56%) or received a delayed prescription (44%). Meanwhile, the remaining 84% of AOM cases received immediate antibiotics. Both groups had …

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