In a double-blind, randomized trial of 1,030 children aged 6 months to 18 years with acute gastroenteritis–associated vomiting, researchers found multidose ondansetron administered at home as needed after emergency department (ED) discharge significantly reduced the incidence of moderate-to-severe gastroenteritis during the subsequent 7 days. Among participants with complete follow-up, 5.1% of the ondansetron group experienced moderate-to-severe gastroenteritis (modified Vesikari score 9 or above) compared to 12.5% in the placebo group (adjusted odds ratio, 0.50; 95% …
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