Researchers found that antibiotics and other commonly prescribed medications substantially increase the risk of Clostridioides difficile infection, and their analysis shows that more drugs impact the gut microbiome than previously believed, as published in Gut. Recent antibiotic exposure (within 30 days) carried the highest risk. Some agents (eg, nitroimidazoles and intestinal anti-infectives) had particularly high odds ratios (OR), likely reflecting treatment-related bias, the authors say. Lipid-lowering agents (aOR 0.8, 95% CI 0.8–0.8) and aspirin (aOR …
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