Journal of Urgent Care Medicine

Amoxicillin Has Slight Advantage Over Amoxicillin-Clavulanate For Acute Sinusitis

In a large observational study of 521,244 adults with acute sinusitis published in JAMA, researchers found outcomes were similar between patients treated with standard-dose amoxicillin-clavulanate and those treated with standard-dose amoxicillin. The study compared outpatient outcomes from 2018 through 2023 for new users of amoxicillin-clavulanate (875–125 mg, 2 times daily) or amoxicillin (875 mg twice daily or 500 mg, 3 times daily). Treatment failure was low overall (3.1%) and did not differ between groups. Only …

Amoxicillin-Clavulanate Shows Slightly More Risk of Issues Than Amoxicillin

In a study of 320,141 children published in JAMA Network, researchers found those treated with amoxicillin-clavulanate had a slightly higher risk of treatment failure (defined as lack of effectiveness or intolerability) compared with amoxicillin. And for those treated with amoxicillin-clavulanate, there was also a higher risk of gastrointestinal symptoms and yeast infections. Accessing treatment in urgent care was more common among patients who received amoxicillin-clavulanate (9.6%) than those who received amoxicillin (5.9%), and urgent care …

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