Routine oral antihistamines provide little benefit for moderate to severe atopic dermatitis, according to a new meta-analysis published in The BMJ. Researchers evaluated 47 trials involving 6,230 children and adults with moderate to severe atopic dermatitis across more than a dozen countries to determine whether adding oral antihistamines improves eczema outcomes. Although second-generation antihistamines (eg, cetirizine, loratadine, fexofenadine) produced statistically significant reductions in eczema severity and itch, the improvements were below established thresholds for clinical …
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