Journal of Urgent Care Medicine

Ondansetron May Not Be Necessary For All Kids After ED Visit For Vomiting

An analysis of persistent vomiting among children in emergency department (ED) presentations found that children under 2 years of age and those with 10 or more episodes of vomiting at presentation were more likely to benefit from ondansetron after discharge than other children. As published in JAMA Network Open, researchers analyzed 977 children with acute gastroenteritis–associated vomiting between September 14, 2019, and June 27, 2024, and found that overall, 8.6% of children had 3 or …

Providing Ondansetron At Home After Gastroenteritis ED Visit Helps Lower Risk For Kids

In a double-blind, randomized trial of 1,030 children aged 6 months to 18 years with acute gastroenteritis–associated vomiting, researchers found multidose ondansetron administered at home as needed after emergency department (ED) discharge significantly reduced the incidence of moderate-to-severe gastroenteritis during the subsequent 7 days. Among participants with complete follow-up, 5.1% of the ondansetron group experienced moderate-to-severe gastroenteritis (modified Vesikari score 9 or above) compared to 12.5% in the placebo group (adjusted odds ratio, 0.50; 95% …

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