DoxyPEP Loses Effectiveness For Gonorrhea Over Time

DoxyPEP Loses Effectiveness For Gonorrhea Over Time

Patients using the doxycycline post-exposure prophylaxis (doxyPEP) treatment protocol typically take a dose of the antibiotic within 72 hours of unprotected sex. DoxyPEP has shown some encouraging real-world effectiveness with significant declines in incidence of bacterial sexually transmitted infections (STIs). However, a new study of 26,582 men who have sex with men and transgender women in California from January 1, 2023, to June 30, 2025, published in The Lancet Infectious Disease, found that doxyPEP remained …

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DoxyPEP May Reduce Use of Antibiotics For STIs 

DoxyPEP May Reduce Use of Antibiotics For STIs 

A study published in the Journal of Antimicrobial Chemotherapy analyzed data from men who have sex with men who were either living with HIV or using HIV pre-exposure prophylaxis. The researchers found that using doxycycline post-exposure prophylaxis (doxyPEP) after unprotected sex significantly reduced the need for antibiotics to treat bacterial sexually transmitted infections (STIs). Between August 2022 and July 2024, 754 men in Italy were prescribed doxyPEP, and 222 (29.4%) reported using it during follow-up. …

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