Journal of Urgent Care Medicine

Doxy-PEP Lowers Syphilis Cases, Directing More Care Toward Pregnant Women

An analysis of surveillance data from January 2017–June 2025 in Washington’s King County area found a health clinic program that offered doxycycline post-exposure prophylaxis (doxy-PEP) starting in March 2023 was associated with substantial declines in syphilis diagnoses. Compared with projected trends, researchers found total cases decreased by 52.3% (3,031 fewer cases), as published in Clinical Infectious Diseases. Reductions were greatest among cisgender men (−53.1%; 2,248 fewer cases) but were also observed in cisgender women (−46.9%; …

DoxyPEP May Reduce Use of Antibiotics For STIs

A study published in the Journal of Antimicrobial Chemotherapy analyzed data from men who have sex with men who were either living with HIV or using HIV pre-exposure prophylaxis. The researchers found that using doxycycline post-exposure prophylaxis (doxyPEP) after unprotected sex significantly reduced the need for antibiotics to treat bacterial sexually transmitted infections (STIs). Between August 2022 and July 2024, 754 men in Italy were prescribed doxyPEP, and 222 (29.4%) reported using it during follow-up. …

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