Patients using the doxycycline post-exposure prophylaxis (doxyPEP) treatment protocol typically take a dose of the antibiotic within 72 hours of unprotected sex. DoxyPEP has shown some encouraging real-world effectiveness with significant declines in incidence of bacterial sexually transmitted infections (STIs). However, a new study of 26,582 men who have sex with men and transgender women in California from January 1, 2023, to June 30, 2025, published in The Lancet Infectious Disease, found that doxyPEP remained …
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