A Canadian trial published in JAMA involving 3,200 primary care patients (56.4% female; median age, 67 years) evaluated the timing of antihypertensive medication administration and found no difference in morning vs bedtime dosing. Over a median follow-up of 4.6 years, bedtime dosing was found to be safe but offered no additional cardiovascular benefit. Rates of major cardiovascular events or death were similar between groups (2.3 vs 2.4 per 100 patient-years; adjusted hazard ratio 0.96, 95% …
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