In a large observational study of 521,244 adults with acute sinusitis published in JAMA, researchers found outcomes were similar between patients treated with standard-dose amoxicillin-clavulanate and those treated with standard-dose amoxicillin. The study compared outpatient outcomes from 2018 through 2023 for new users of amoxicillin-clavulanate (875–125 mg, 2 times daily) or amoxicillin (875 mg twice daily or 500 mg, 3 times daily). Treatment failure was low overall (3.1%) and did not differ between groups. Only …
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