A large international study found that direct oral challenge (DOC) can be a safe and effective strategy for identifying patients who have a true penicillin allergy. Researchers evaluated hospitalized adults who self-reported a penicillin allergy—a label that historically is attached to about 10% of patients, according to the study presented in Clinical Infectious Diseases. Among the 5,121 patients assessed, 30.7% underwent DOC; of these, 95.5% (95% confidence interval, 94.3%–96.5%) were safely “delabeled,” after assessing and …
Read More

