The Resolution


Differential Diagnosis

  • Cryoglobulinemia
  • Autoerythrocyte sensitization
  • Vitamin K deficiency
  • Ehlers-Danlos syndrome




The correct diagnosis is autoerythrocyte sensitization, also known as Gardner-Diamond syndrome or psychogenic purpura. This disorder is characterized by bruising without clear precipitating causes or definite trauma.

Learnings/What to Look for

  • Autoerythrocyte sensitization has been associated with psychiatric illness, sometimes subtle and without initial obvious symptoms
  • Bruises are painful, vary in size, and may have peculiar or geometric shapes
  • Associated symptoms include abdominal pain, nausea, vomiting, diarrhea, and headache
  • Prodromal symptoms such as pain, warmth, or itching at the site prior to the bruising have been described


Pearls for Urgent Care Management and Considerations for Transfer

  • Diagnosis is by history, physical examination, and laboratory tests to rule out bleeding disorders
  • Onset may follow a traumatic event or in the context of severe psychosocial stress. Associated psychiatric abnormalities include depression and anxiety, borderline personality disorder, and obsessive-compulsive disorder
  • Once other, physical disorders have been ruled out, referral for psychiatric therapy is warranted
A Teenage Girl Who Suddenly Bruises Easily
Share this !