Abstracts

Prevention of RSV Disease in Healthy Infants Take Home Point: In this early phase, drug-manufacturer-funded clinical trial, a single dose of clesrovimab reduced the incidence of respiratory syncytial virus (RSV)-associated medically attended lower respiratory infection and RSV-associated hospitalization, with a safety profile similar to that of a placebo. Citation: Zar HJ, Simões E, Madhi S, et. al. Clesrovimab in Infants and Children at Increased Risk for Severe RSV Disease. New Eng J Med. 2025:393, 13;1292-1303. Relevance: RSV is a common cause of morbidity and mortality in infants worldwide. Prevention utilizing …
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Causes, Management, and Outcomes of Diplopia in the ED Take Home Point: For diplopia, binocular diplopia was the most common presentation to the emergency department (ED), with microangiopathies and strokes being the most common etiology. Citation: Occelli C, Coffin V, Raynaud O, et. al. Presentation, management and outcomes of patients with diplopia in the emergency department. Am J Emerg Med. 2025;96:170-175. doi: 10.1016/j.ajem.2025.06.024. Relevance: Patients with diplopia occasionally present to ED and urgent care (UC) with neurological or ophthalmological causes, some of which require immediate attention. Study Summary: This was …
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Validation of Clinical Predictive Rules in Pediatric Testicular Torsion Take Home Point: In this study, the Testicular Emergency Score for Torsion (TEST) identifies a larger group of patients at low risk for testicular torsion suitable for safe management without Doppler ultrasound compared to the other clinical validation scores. Citation: Valdivieso-Castro M, Vázquez-Gómez L, Olabarri M, et. al. Clinical Prediction Rules for Identifying Children With Testicular Torsion: A Multicenter Prospective Study. Pediatr Emerg Care. 2025 Aug 1;41(8):620-627 Relevance: Acute nontraumatic unilateral testicular pain is a common presentation to urgent care and/or …
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Cannabis Use and Cardiovascular Outcomes in Adults Take Home Point: This study suggests that cannabis use has a strong, statistically significant association with adverse cardiovascular outcomes independent of tobacco use. Citation: Jeffers A, Glantz S, Byers A, et. al. Association of Cannabis Use With Cardiovascular Outcomes Among US Adults. J Am Heart Assoc. 2024 5;13(5):e030178. doi: 10.1161/JAHA.123.030178 Relevance: Animal studies have previously shown endothelial cell dysfunction, a precursor to endovascular disease, occurs with cannabis use. However, with increased cannabis use in recent years, it is unknown if a correlation exists …
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Casting Rather Than Surgery for Medial Epicondyle Fractures in Children Take Home Point: In this randomized trial, treatment for pediatric displaced medial epicondyle fractures with casting alone was noninferior to the traditional surgical fixation and casting at the12-month follow-up period. Citation: Grahn P, Helenius I, Hämäläinen T, et. al. Casting vs Surgical Treatment of Children With Medial Epicondyle Fractures: A Randomized Clinical Trial. JAMA Netw Open. 2025 May 1;8(5):e258479. doi: 10.1001/jamanetworkopen.2025.8479. Relevance: Medial humeral epicondyle fractures account for 12-20% of all pediatric elbow fractures. There is currently no consensus regarding …
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